Optimal Ventilation for Cardiac Arrest

Study Status: Recruiting

Pediatric cardiac arrest is a life-threatening problem affecting >15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.

Sex: ALL
Minimum Age: 37 Weeks
Maximum Age: 18 Years

Researchers look for people who fit a certain description, called eligibility criteria. Below are the inclusion and exclusion criteria for study participants:

Inclusion Criteria

Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
Received at least 1 minute of CPR.

Exclusion Criteria

Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
Brain death determination prior to the CPR event.
Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Conditions

Cardiac Arrest (CA)

Intervention/Treatment

OTHER : OPTI-VENT Bundle
OTHER : Transition
OTHER : None - control

Sponsor

Children's Hospital of Philadelphia

Principal Investigator(s)

Robert Sutton, MD, MSCE, PRINCIPAL_INVESTIGATOR, Children's Hospital of Philadelphia